In 2021 heeft het NCSC de Universiteit Leiden gevraagd om een rapid review uit te voeren naar best practices en mogelijkheden voor vervolgonderzoek over de integratie van gedragswetenschappen in security by design methodologieën en projecten. Dit academische veld wordt security by behavioural design…

De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Patterned detectors are an existing technology that can be found in almost all color cameras.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…

Quantum Leiden werkt met een aantal bedrijven samen. Bijvoorbeeld om te kijken hoe deze bedrijven de ontwikkelde quantumtechnologieën kunnen toepassen.

Wil je aan de slag met Designing Your Life-onderwijs? Deze website heeft alles wat je nodig hebt!

Bestuursprocesrecht in constitutioneel-rechtsvergelijkend perspectief.

In the first part of this thesis we study the geometry of folding patterns.

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Zojuist verschenen: Nederlands internationaal privaatrecht Special issue: Private international law and finance

Promotores: J. Kok, M. Chaudron (Chalmers University)

Damien Van Puyvelde en Paul Oling onderzoeken hoe overheidsinlichtingendiensten effectief kunnen samenwerken met de private technologiesector om aan hun veranderende technologische behoeften te voldoen.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Op 9 september 2020 verdedigde Ruben de Graaff zijn proefschrift 'Concurrence in European Private Law'. Het promotieonderzoek is begeleid door promotoren prof.mr. A.G. Castermans en prof.mr. S.C.G. Van den Bogaert.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: Prof.dr. T.H.W. Bäck

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

De eerste index om de veiligheid, duurzaamheid en circulariteit van producten te meten, waarmee ze het EU-kader (SSbD) operationaliseren.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Op 17 oktober 2018 verdedigde Henriëtte Weststrate haar proefschrift 'De Notaris en Private Rechtspraak'. Het promotieonderzoek is begeleid door promotoren prof. dr. H.J. van der Herik en prof. mr. G.J. Meijer.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Bij onderwijsvernieuwing wordt vaak nascholing ingezet, maar die is niet altijd effectief. In haar proefschrift onderzocht Nienke Wieringa (ICLON) welke ondersteuning docenten nodig hebben bij onderwijsvernieuwing.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.