130 zoekresultaten voor “translational” in de Publieke website
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Translational Symmetry Breaking in Holographic Strange Metals
In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality.
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Modifying a post-translational modification
Promotie
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LED3 Lecture: Translational PKPD for novel modalities
Lezing
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Optoelectronic cardiac rhythm control: a translational exploration
Promotie
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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It's about time
This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.
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DNA-herstel onder de loep: het samenspel van eiwitmodificaties
Hoe werken post-translationele eiwitmodificaties—chemische veranderingen van eiwitten nadat ze zijn gemaakt—samen om DNA te herstellen, en hoe kan dit ons helpen ziektes te begrijpen?
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Characterization of age-associated immunity in atherosclerosis
Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Advancing the LeiCNS-PK3.0 model for prediction of CNS Pharmacokinetics Nonlinear BBB Transport, Inter-species Scaling, and Machine Learning
This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Tail Regeneration in the Tokay Gecko (Gekko gecko)
Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Lost in translation: The toll-like receptor 7 induced pharmacological challenge model of the skin
This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.
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Arabidopsis AGC3 kinases and PIN plasma membrane abundance
The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Periodic pulse solutions to slowly nonlinear reaction-diffusion systems
Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Synthetic Affinity-Based Probes for ADP-Ribose Interactome Studies
Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.
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Translational studies on immunologic biomarkers and precision therapy in ovarian and breast cancer
Promotie
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Mutation-Driven Modulation of GPCR Pharmacology: Insights from Adenosine and Serotonin Receptors
This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.
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RARE-NL gaat op zoek naar behandelingen voor zeldzame ziekten
RARE-NL, een nieuw samenwerkingsverband van diverse universitaire ziekenhuizen, gaat op zoek naar behandelingen voor zeldzame ziekten. Namens het LUMC neemt hoogleraar Teun van Gelder deel aan het initiatief.
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Mark van Buchem -
biology exploration of the Ubiquitin and Ubiquitin-like post-translational machinery
Promotie
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Multi-faceted dissection of innate myeloid cell heterogeneity: a translational approach for application in patient care
Promotie
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M Malessy -
Albert Dahan -
Geert Jan Groeneveld -
Antistoffen tegen reumatische ziektes direct getest in patiënten
Hans Ulrich Scherer, Leidse hoogleraar translationele reumatologie, staat met zijn ene been in de kliniek, waar hij patiënten helpt. Daarnaast begeleidt hij onderzoekers in het laboratorium. In zijn zoektocht naar reumatische auto-immuunziektes slaat hij een brug tussen beide werelden.
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Leerlijn Suïcidepreventievaardigheden: van onbewust onbekwaam naar bewust bekwaam
Een doorlopende leerlijn suïcidepreventie biedt psychologiestudenten essentiële kennis en vaardigheden om suïcidaliteit effectief te herkennen en het gesprek erover aan te gaan.
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Frank Baas -
Marieke Wermer -
Teun van Gelder -
Raymund Roos -
Gentherapie met geïmplanteerd LED-lampje stopt hartritmestoornis automatisch
Onderzoekers van het LUMC hebben, in samenwerking met de TU Delft, een manier gevonden om een op hol geslagen hart, automatisch en direct te resetten met een geïmplanteerd LED-lampje.
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Asina Gijasi -
Dina Berlina -
Johannes Verschuuren -
Annemieke Aartsma-Rus -
Robert Vermeiren -
Camiel Boon -
Onno Meijer -
Andrew Webb -
Nienke Biermasz