Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Hetterscheid

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: B.van de Water, Co-promotor: L.S.Price

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Lezing

Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Op 29 april 2020 verdedigde Beth Van Schaack haar proefschrift 'Imagining Justice for Syria: Water Always Finds Its Way'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: Prof.dr. J. Kuiper

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Promotor: Prof.dr. P. Stevenhagen

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda