Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotor: H.W. Lenstra

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

In this thesis we study products of linear error correcting codes.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Promotor: Prof.dr. H.V.J. Linnartz