Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Klinische psychologie richt zich vooral op de toepassing van wetenschappelijke psychologische kennis op assessment, preventie en behandeling van psychopathologie.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Het gebruik van ‘Big data’ is niet meer weg te denken binnen het wetenschappelijk onderzoek. Voor dit onderzoek maken we gebruiken van diverse grote databestanden.

Promotor: J. Zaanen

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: Prof.dr. M.L. van Hecke

Van oudsher werden donder en bliksem gezien als Gods strafwerktuigen. De uitvinding van de bliksemafleider door Benjamin Franklin in 1752 bracht hierin echter verandering. Welke gevolgen hadden de uitvinding en invoering van de bliksemafleider voor de manier waarop men aankeek tegen het onweer? Jan…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Control of infectious diseases poses continuous challenges for human health.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Promotor: C.J. ten Cate

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Consequences for sediment stability and seston trapping

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…