Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotores: F.H. van Lunteren, F.P. Israel

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Tijdens de vroege moderne tijd werden veel middeleeuwse manuscripten in stroken perkament gesneden, die opnieuw werden gebruikt om de bindingen van nieuw gedrukte boeken te versterken. Tot voor kort kwamen deze hergebruikte stukjes middeleeuwse manuscripten alleen aan het licht wanneer de vroege moderne…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

With tomography it is possible to reconstruct the interior of an object without destroying.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Tussen 1683 en 1795 werd Suriname bestuurd door de Sociëteit van Suriname, een samenwerkingsverband tussen het stadsbestuur van Amsterdam, de West-Indische Compagnie en de familie Van Aerssen van Sommelsdyck. Terwijl de hoogtijdagen van de Gouden Eeuw al voorbij waren bloeide Suriname gedurende het…

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Promotor: F. Arbab

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This research focuses on the distribution of chemical elements in protoplanetary disks, the birthplaces of planets. These disks form around young stars and contain gas and dust, from which planets grow. Ice plays a crucial role in planet formation, aiding the clumping of dust particles and influencing…

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Promotor: A. Kros