De programmagroep Onderzoeksmethoden en Statistiek heeft brede expertise op het gebied van onderzoeksmethodologie.

Promotor: Prof.dr.ir. E. Deprettere

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotor: H.V.J. Linnartz

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Bekijk de opleidingsvideo van Wiskunde en ontdek waarom Wiskunde universeel toepasbaar is. Met veel keuzemogelijkheden.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: Prof.dr. A. Achucarro

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Het Center for Legal Entrepreneurship and Innovation (CLEI) richt zich op het stimuleren van ondernemerschap en innovatie in de juridische bedrijfstak.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Het Empower your PhD-project wil bereiken dat Leidse promovendi meer zelfregie krijgen over hun persoonlijke en loopbaanontwikkeling.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

LiDAR is een relatief nieuwe meettechniek waarmee het Actueel Hoogtebestand Nederland het hele land zeer nauwkeurig mee heeft ingemeten. Het grote voordeel van deze manier van meten is dat vegetatie geen belemmering vormt. Hierdoor kunnen ook gebieden waar vegetatie de zichtbaarheid van de ondergrond…

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotor: M.L. van Hecke

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Op 28 januari 2021 verdedigde Dorine Verheij haar proefschrift 'Credit rating agency liability in Europe'. Het promotieonderzoek is begeleid door promotoren prof.mr.drs. M. Haentjens en prof.mr. A.G. Castermans.

Is de kwaliteit van het huidige toezicht en handhaving door de overheid dusdanig dat hiermee de bedrijven die met grote hoeveelheden gevaarlijke stoffen werken tot naleving van de wet- en regelgeving worden gebracht?

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Het onderzoek van de sectie Sociale, Economische en Organisatiepsychologie is gericht op het ontwikkelen van modellen om beïnvloeding in sociale systemen te beschrijven en te verklaren. Dit wordt onderzocht binnen het domein Sociale en Organisatiepsychologie, en ook binnen de Economische en Consumen…

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Lezing

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

In december 2024 verscheen bij Cambridge University Press het boek Regulating Competition in the Digital Network Industry van dr. Jasper van den Boom, assistent-professor EU-mededingingsrecht aan het Europa Instituut van de Universiteit Leiden. Het boek introduceert een nieuw analytisch kader voor het…

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Lezing

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Onderzoek naar de onderliggende principes van de menselijke taal.

LEGITIMULT onderzoekt hoe Covid-19-maatregelen van overheden invloed hebben op multilevel governance en democratisch bestuur in 31 Europese landen

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

Promotie