This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Promotor: K.H. Kuijken

Promotor: Prof.dr. H.L.V. Linnartz

Gebruik en ontwikkel je talenten.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

This thesis covers various applications of topology in condensed matter physics and quantum information.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Zowel met spel als politiek kunnen werelden worden geschapen waarin nieuwe regels gelden, betekenissen worden gecreëerd en mogelijkheden ontstaan voor samenwerking, strategie en creatieve oplossingen. In die zin hebben spel en politiek altijd veel gemeen gehad. Maar wat gebeurt er met deze verwantschap…

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

This thesis is about cosmological inflation and its relation to observations.

Promotor: W. Jiskoot, Co-promotor: A. Kros

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Een historische blik achter de betonnen schermen van de Amerikaans-Nederlandse betrekkingen.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Kijk mee en praat mee over de wetenschap van het verleden tijdens wekelijkse Let’s Plays van populaire games en vodcasts op het livestreamplatform Twitch.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

Lezing

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

Het Instituut voor Geschiedenis heeft een LinkedIn pagina opgezet voor studenten en alumni van de studie Geschiedenis in Leiden. Dit is een professionele online community waar je op de hoogte blijft van interessante stages, werkplekken en evenementen. Een digitale ontmoetingsplek voor iedereen die ooit…

Een dag na de inauguratie van Donald Trump als nieuwe president van de Verenigde Staten werden zoektermen gelieerd aan Biden, Harris en Obama op Instagram aangemerkt als ‘gevoelige content’. Promovendus Danny Mekic waarschuwt in de Volkskrant voor techbedrijven: ‘Extreem onwenselijk’.

Danny Mekić, promovendus bij eLaw - Centrum voor Recht en Digitale Technologie én Eindhoven University of Technology, is op 22 juli uitgeroepen tot ‘Mr. van de Week’ omdat hij recentelijk twee rechtszaken tegen het socialemediabedrijf Twitter heeft gewonnen.

In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.