Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Promotor: M.A.G.J. Orrit

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

De tweejarige masteropleiding Physics wordt aangeboden door het Leids Instituut voor Onderzoek in de Natuurkunde. De opleiding is theoretisch en experimenteel. Er is ruime aandacht voor onderzoekstraining. Ook bieden we veel keuzemogelijkheden en op maat gemaakte, individuele studieprogramma’s.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Waterdruppels zweven in een hete pan vanwege het zogenoemde Leidenfrost-effect. Nu hebben natuurkundigen een variatie ontdekt: het Elastische Leidenfrost-effect. Het verklaart waarom hydrogel balletjes op een hete plaat rondspringen en hoge piepgeluidjes maken. Publicatie in Nature Physics op 24 jul…

Hoe complexer het voorwerp, des te ingewikkelder het is om op te vouwen. Een ruimtevaartuig heeft al snel vele motortjes nodig om een instrument-arm in elkaar te vouwen en mensen hebben zelfs moeite met een wegenkaart. Natuurkundigen uit Leiden en Amsterdam hebben nu een structuur ontworpen die zichzelf…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

To study how planetary systems come into existence we study much younger systems still in formation.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

In the first part of this thesis we study the geometry of folding patterns.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Promotores: G. Persoon, R. Schefold

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotor: Prof.dr. M. Ubbink

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Nieuw onderzoek van de National University of Singapore en Leiden laat zien dat chimpansees en bonobo’s net zoveel contrast in hun ogen hebben als mensen, waardoor ze gemakkelijk de richting van iemands blik kunnen volgen.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.