Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

De tweejarige masteropleiding Physics wordt aangeboden door het Leids Instituut voor Onderzoek in de Natuurkunde. De opleiding is theoretisch en experimenteel. Er is ruime aandacht voor onderzoekstraining. Ook bieden we veel keuzemogelijkheden en op maat gemaakte, individuele studieprogramma’s.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Promotor: M.A.G.J. Orrit

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Als je een elastiekje uitrekt, wordt het langer. Maar stel je eens voor dat een materiaal juist korter wordt als je eraan trekt. Dat klinkt raar, niet? Toch is dat precies wat natuurkundigen van de Universiteit Leiden, AMOLF en ARCNL voor elkaar hebben gekregen.

Waterdruppels zweven in een hete pan vanwege het zogenoemde Leidenfrost-effect. Nu hebben natuurkundigen een variatie ontdekt: het Elastische Leidenfrost-effect. Het verklaart waarom hydrogel balletjes op een hete plaat rondspringen en hoge piepgeluidjes maken. Publicatie in Nature Physics op 24 jul…

Hoe complexer het voorwerp, des te ingewikkelder het is om op te vouwen. Een ruimtevaartuig heeft al snel vele motortjes nodig om een instrument-arm in elkaar te vouwen en mensen hebben zelfs moeite met een wegenkaart. Natuurkundigen uit Leiden en Amsterdam hebben nu een structuur ontworpen die zichzelf…

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

To study how planetary systems come into existence we study much younger systems still in formation.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Tin electrodeposition applications have rapidly evolved in the past 25 years.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Promotores: G. Persoon, R. Schefold

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

In the first part of this thesis we study the geometry of folding patterns.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Studievoorlichting

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…