Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Op 2 en 3 oktober 2017 heeft een delegatie van de Afdeling Jeugdrecht deelgenomen aan de 15e Europese regionale conferentie van de International Society for the Prevention of Child Abuse and Neglect in Den Haag.

Nederland heeft een lange geschiedenis met door steekmuggen overgedragen ziekten, met name malaria, tot het in 1970 malariavrij werd verklaard.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Heart failure is a major health care problem with high mortality.

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Promotores:Th.J.C. van Berkel, M. van Eck

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Verken de wereld van geesteswetenschappen aan de Universiteit Leiden. Ontdek een breed scala aan studies in talen, culturen, geschiedenis, filosofie en meer. Sluit je aan bij een gemeenschap die de wereld begrijpt en vormgeeft.

Promotie

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Promotor: S.M. Verduyn Lunel

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Deze cursus is ontwikkeld samen met de vakgroep Violence and Violence Prevention van het Institute of Security and Global Affairs.

Machine Learning is becoming a more and more substantial technology for industry.

Cardiovascular disease is the leading cause of death worldwide.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Het is een gevaarlijke virusuitbraak, maar het is nog onder controle te krijgen. Dat stelde viroloog Ann Vossen van het LUMC in tv-programma Jinek. Maar de uitspraak van de Chinese gezondheidsautoriteit dat het virus al kan worden overgedragen terwijl mensen nog geen symptomen hebben, gelooft Vossen…

Promotor: G.J.B. van Ommen

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

Promotie

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Het doel van dit project is het monitoren van levensdelicten in de Dutch Caribbean.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Control of infectious diseases poses continuous challenges for human health.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Dit artikel verkent het complexe onderwerp vuurwapengeweld en benadrukt het belang van het opnemen van niet-dodelijke incidenten van vuurwapengeweld.

Dit artikel introduceert het concept van vergelijkingsrepertoires om te verklaren hoe bepaalde vergelijkingen diep verankerd raken in de maatschappij.