256 zoekresultaten voor “evidence basis” in de Publieke website
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E-values for anytime-valid inference with exponential families
Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.
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Partnerschap: Verder met Publiek Leiderschap
In het programma ‘Verder met Publiek Leiderschap’ werkt het Leiden Leadership Centre samen met zeven verschillende publieke organisaties om gezamenlijk leiderschap te onderzoeken en verder te ontwikkelen.
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Onderwijs
Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.
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Onderwijs
De programmagroep verzorgt onderwijs op het gebied van diagnostiek, behandeling/preventie/interventie, neuropsychologisch onderzoek, gedragsobservaties, klinische vaardigheden, gesprekstechnieken, ondersteuning van leerkrachten en ouders, kennis over verstandelijke beperkingen en ontwikkelingsstoornissen…
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Empower your PhD project
Het Empower your PhD-project wil bereiken dat Leidse promovendi meer zelfregie krijgen over hun persoonlijke en loopbaanontwikkeling.
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Leidse wetenschappers pakken kanker aan de basis aan
Kanker is tegenwoordig de belangrijkste doodsoorzaak in Nederland. Ieder jaar wordt op Wereldkankerdag (4 februari) extra stil gestaan bij de gevolgen en mogelijke bestrijding van deze ziekte. Biowetenschappers van de Universiteit Leiden onderzoeken kanker op fundamenteel niveau en staan daarmee aan…
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ISA – Interventie voor Sociale Angst bij kinderen en jongeren
De sociale angststoornis is één van de meest voorkomende stoornissen bij kinderen en jongeren. Sociale angst wordt gekenmerkt door overmatige angst en vermijding van sociale situaties, waarbij kinderen voornamelijk bang zijn om negatief beoordeeld te worden door anderen. Cognitieve gedragstherapie,…
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From intracluster medium dynamics to particle acceleration
The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.
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Combining classic and novel tools in the study of Historical Collections of Chinese Materia Medica in the Netherlands
Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…
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Leiden Institute for Brain and Cognition
Het Leiden Institute for Brain and Cognition (LIBC) is een Leids Universitair netwerk dat zich richt op het stimuleren van interdisciplinaire samenwerking op het gebied van hersenen en cognitie. Daarnaast maakt het LIBC zich sterk voor wetenschappelijke valorisatie en outreach.
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Onze aanpak
Het Academia in Motion-programma faciliteert het creëren van een open knowledge community door:
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Urban green infrastructure for biodiversity and ecosystem services
Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.
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‘Houd die open blik’
Prikkelende vragen stellen om de verdieping op te zoeken, zo ziet Stella Trompet haar studenten groeien. Ze is docent bij de halve minor en master Health, Ageing and Society van het LUMC/Universiteit Leiden. Haar enthousiasme brengt ze over op haar studenten, want ouderen zitten niet achter de geraniums,…
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Medicijngebruik door adoptiekinderen
Internationaal geadopteerde kinderen gebruiken niet meer medicijnen dan hun niet-geadopteerde leeftijdgenoten.
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Lopende projecten
De onderzoeksprojecten binnen eLaw richten zich op baanbrekende en toekomstgerichte maatschappelijke uitdagingen op het snijvlak van recht en technologie.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Notitie voor jeugdrechters over gehechtheid bijgewerkt
Emeritus hoogleraar Adoptiestudies Femmie Juffer heeft haar onderzoeksrapport 'Beslissingen over kinderen in problematische opvoedingssituaties - Inzichten uit gehechtheidsonderzoek' uit 2010 op verzoek van de Expertgroep Jeugdrechters bijgewerkt met recente wetenschappelijke kennis over gehechtheid.…
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On electronic signatures of topological superconductivity
Promotor: Prof.dr. C.W.J. Beenakker
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Spectral Analysis of Inhomogeneous Networks
This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Monsters in the Deep: Using simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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Fostering Curiosity Through Video Games
This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.
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Theoretische taalkunde
Onderzoek naar de onderliggende principes van de menselijke taal.
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A radio view of dust-obscured star formation
Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.
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Ginsenosides as selective glucocorticoid drugs: agonists, antagonists, and prodrugs
Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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Expanding the coverage of ecosystem services in life cycle assessment: an interdisciplinary venture
To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.
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Behavioral Public Administration Lab
The Behavioral Public Administration Lab (BPA Lab) conducts behavioral science to generate, share, and apply insights about human behavior to improve governance, policy, and management in the public sector.
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Sizing up protoplanetary disks
This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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The dust and molecular gas in the torus of NGC 1068
An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Business incubators: the impact of their support
A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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On the 16-rank of class groups of quadratic number fields
Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)
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Measuring gold molecular gas across cosmic time
Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Glycosyl Cations in Glycosylation Reactions
This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.
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Atmospheres of hot alien Worlds
Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller
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Comparative genomics of the balanced lethal system in Triturus newts
All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?
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Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
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Spectral signatures of breaking of ensemble equivalence
This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…
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Microstructural and Metabolic Alterations in the Zebrafish Brain Induced by Toll-Like Receptor 2 Deficiency
Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Kinderen met een licht verstandelijke beperking in het passend onderwijs
Mariëtte Huizinga, Dorien Graas en Anika Bexkens vragen aandacht voor leerproblemen van leerlingen met een licht verstandelijke beperking in de klas. Met hun nieuwe boek willen zij het leerkrachten makkelijker maken om aan te sluiten bij de specifieke onderwijsbehoeften van deze kinderen.
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).