In this thesis, we present new laboratory data of interstellar dust analogues.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: Prof.dr. J.W.M. Frenken

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

De Universiteit Leiden is sinds eind jaren negentig gevestigd in twee steden: Leiden en Den Haag. Ook de Faculteit der Rechtsgeleerdheid biedt op de Campus Den Haag onderwijs en onderzoek aan.

Promotor: Prof.dr. M. de Jong

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

In de ontwikkeling van de Humanities Campus worden zowel bij de gebouwen als bij het omringende gebied, zoveel mogelijk 'groene keuzes' gemaakt. De verduurzaming van de campus krijgt vorm aan de hand van beoordelingsmethode BREEAM-NL.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Participants in this course will learn to support student teachers and new colleagues in their professional development as teachers, with particular emphasis on the context of bilingual or international education, as in the ICLON World Teachers Programme (WTP).

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Kijk regelmatig op deze pagina voor meer informatie over het vergroten van de biodiversiteit aan de Universiteit Leiden.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Promotie

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Jan van den Berg heeft zij proefschrift op 8 november 2018 verdedigd.

Het WARN-project heeft als doel te begrijpen waarom sommige waarschuwingen niet effectief genoeg zijn of niet tijdig de juiste besluitvormers bereiken om een crisis af te wenden.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Jaroslaw Kantorowicz and Rok Spruk onderzoeken de bijdrage van institutionele hervormingen aan economische groei.

Religion and ethnicity are inextricably linked in discourse within and about Central Asia. One common narrative suggests that as a result of differences between historically sedentary and nomadic populations, ethnic Tajiks and Uzbeks are naturally more religious and more likely to radicalise than their…

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

Promotie

In dit proefschrift onderzochten we hoe we kankerbehandelingen slimmer en veiliger kunnen doseren. Veel middelen worden nog volgens een “one size fits all”-schema gegeven, vaak gebaseerd op de maximaal verdraagbare dosis. Dat kan leiden tot onnodig veel bijwerkingen, behandelingonderbrekingen en hoge…

Promotie

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.