Promotores:Th.J.C. van Berkel, M. van Eck

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Inhoudelijk blijft het programma van deze internationale interdisciplinaire master van de Universiteit Leiden hetzelfde. De nieuwe naam dekt de inhoud van het programma beter en zo wordt de herkenbaarheid voor studenten en het werkveld vergroot.

Op 21 november 2018 verdedigde Lieke Kools haar proefschrift 'Essays on wealth, health, and data collection'. Het promotieonderzoek is begeleid door promotoren prof. dr. K.P. Goudswaard en prof. dr. C.L.J. Caminada.

Dit boek onderzoekt hoe zorgen over de volksgezondheid en politieke agenda’s elkaar in de VS de afgelopen eeuw hebben beïnvloed.

De Keuzegids is een onafhankelijke consumentengids die alle (master)opleidingen in Nederland met elkaar vergelijkt. Studenten beoordelen de opleidingen op inhoud, sfeer, docenten, toetsing en voorbereiding loopbaan.

Promotores: H.A. Udo De Haes, P.M. Brakefield

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.

Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Promotie

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Promotor: Prof.dr. L.J. Slikkerveer

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Cardiovascular syndromes are the major cause of death in Western societies.

Over the past two centuries, socioeconomic development has improved material living standards but has also intensified environmental pressures, including climate change and biodiversity loss.

Nederland heeft een lange geschiedenis met door steekmuggen overgedragen ziekten, met name malaria, tot het in 1970 malariavrij werd verklaard.

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. J. Kuiper

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Wereldwijd hebben miljoenen kinderen te maken met ziektes die relatief makkelijk te voorkomen zijn. Sarah Spronk onderzocht de vraag welke prioriteiten voortvloeien uit het recht op gezondheid van kinderen om vervolgens kindgerichte gezondheidszorg te kunnen vormgeven.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Het duurt vaak lang voordat iemand met een eetstoornis hulp zoekt en behandeld wordt. Volgens promovendus Pieter Rohrbach biedt E-Health oplossingen.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Onderzoeken hoe gegevens afkomstig van draagbare technologieën kunnen worden gebruikt om effectieve gedragsveranderingen te identificeren die hopelijk zullen leiden tot gezondheidsverbeteringen.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotie

Promotie

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

How can we bridge the gap between experts and the general public?

Hoe kunnen nierpatiënten geholpen worden een gezonde leefstijl aan te nemen? Gezondheidspsycholoog Sandra van Dijk gaat dit onderzoeken met een persoonsgebonden subsidie van de Nierstichting.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Control of infectious diseases poses continuous challenges for human health.