Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Control of infectious diseases poses continuous challenges for human health.

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: B. van de Water

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. T. Hankemeier

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

De beschrijvende taalkunde aan het LUCL omvat de documentatie en de beschrijvende analyses van minder-bestudeerde talen en de typologische en historische vergelijkingen tussen talen.

Promotor: B.van de Water, Co-promotor: L.S.Price

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotor: Prof.dr. H.J.A. Rottgering

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Plants rely on multilayered immune systems to detect and restrict pathogen invasion while minimizing damage to host tissues. This thesis investigates the regulation, spatial organization, and functional consequences of effector-triggered immunity (ETI) in Arabidopsis thaliana.

The Minor in Business Administration teaches business knowledge and skills that are important for your future career.

The minor Artificial Intelligence & Business (previous name Science, Business, and Innovation) will provide you with knowledge and skills in the area of management and entrepreneurship, with a focus on issues in technology-driven companies.