Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Hersenstimulatie en voedingssupplementen zoals tyrosine of tryptofaan lijken veelbelovende opties om de cognitieve prestaties te verbeteren. Dat constateert psycholoog Laura Steenbergen. Maar ze stelt ook dat er meer onderzoek nodig is. Promotie op 16 juni.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

De sectie Cognitieve Psychologie draagt bij aan de 3-jarige bacheloropleiding en verzorgt 2 masterspecialisaties.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Promotor: Prof.dr. A.W. van der Vaart

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: A.P. IJzerman

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Promotor: J. A. Bouwstra

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Cognitieve psychologie is de studie van mentale functies, waaronder aandacht, geheugen, bewustzijn, emotie, taal en actiecontrole. Het doel is om de complexe relaties tussen brein, cognitie en gedrag te begrijpen.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

Nauwkeurig emoties van anderen herkennen is een essentiële sociale vaardigheid, die relevant is voor het omgaan met de sociale wereld vanaf de kindertijd. Het vermogen van kinderen om dit te doen is een mijlpaal in hun sociaal-emotionele ontwikkeling en wordt geassocieerd met een aantal belangrijke…

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

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Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Promotor: A.W. van der Vaart

Promotor: Prof.dr. G.P. van Wezel

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Cardiovascular syndromes are the major cause of death in Western societies.

Heart failure is a major health care problem with high mortality.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. J. den Hertog

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans