Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

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Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Heart failure is a major health care problem with high mortality.

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

Promotores:Th.J.C. van Berkel, M. van Eck

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Promotor: S.M. Verduyn Lunel

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Hoogleraar Annemarie Meijer en dr. Sander Wezenberg ontvingen op 24 januari een NWO-subsidie voor hun onderzoek. De subsidie is toegekend binnen het Open Competitie ENW-M-programma en is bedoeld voor vernieuwende onderzoeksgebieden die de basis kunnen zijn voor onderzoeksthema’s van de toekomst.

Machine Learning is becoming a more and more substantial technology for industry.

Cardiovascular disease is the leading cause of death worldwide.

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Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Waarom zijn mycobacteriën zulke succesvolle ziekteverwekkers? En zijn er verdedigingsmechanismen in het lichaam die helpen een infectie iets te verminderen? Om dit te achterhalen, heeft Annemarie Meijer de NWO Open competitie ENW-XL-beurs toegekend gekregen. Ze gaat niet alleen aan de slag. Aan het…

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

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Promotor: G.J.B. van Ommen

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Control of infectious diseases poses continuous challenges for human health.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Onderzoekers moeten in een gespecialiseerde omgeving werken zodra ze aan de slag gaan met gevaarlijke bacteriën en virussen. Alleen in laboratoria met een hoog bio-veiligheidsniveau mogen ze deze microben bestuderen. Helaas zijn dure microscopen nodig om de microben goed te bekijken, maar is dat soms…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Antibiotica, bacteriën en resistentie zijn zeer geschikte onderwerpen voor een profielwerkstuk. Hier vind je alvast een aantal handige links.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…

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