Promotor: Prof.dr. J. Kuiper

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: Prof.dr. J.P. Abrahams

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Nederland heeft een lange geschiedenis met door steekmuggen overgedragen ziekten, met name malaria, tot het in 1970 malariavrij werd verklaard.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Heart failure is a major health care problem with high mortality.

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

Promotores:Th.J.C. van Berkel, M. van Eck

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Promotor: S.M. Verduyn Lunel

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotie

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Er is weer nieuws over het eiwit alpha-Synucleine. dat een belangrijke rol wordt toegedicht bij de ziekte van Parkinson. Biofysicus Martina Huber e.a. laten zien op welke manier deze eiwiten samenklonteren als ze met een membraan in contact komen. Hun artikel in de Journal of the American Chemical Society…

Met het onderzoek ‘Baby’s eerste hapjes’ willen wij meer te weten komen over de overgang naar vast voedsel bij baby’s. Zo zijn we benieuwd hoe de overgang naar vast voedsel bij kinderen verloopt, hoe het eetpatroon van kinderen zich na de overgang verder ontwikkelt en hoe ouders deze overgang en het…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Postdoc Lucia Bossoni heeft een NWO Veni in de wacht gesleept. Ze gebruikt de beurs om de komende drie jaar onderzoek te doen naar hersenziekten in labs op zowel het LUMC als het Leidse natuurkunde-instituut.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Cardiovascular disease is the leading cause of death worldwide.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

De Academy of Creative and Performing Arts biedt in samenwerking met een aantal instellingen voor hoger onderwijs in de kunsten, twee PhD-programma’s aan: in de muziek (docARTES) en de beeldende kunst en vormgeving (PhDArts). Deze programma's zijn beide internationale doctoraatsprogramma's voor praktijkgericht…

Bekijk de aftermovies voor een sfeerimpressie van voorgaande runs.

Promotor: G.J.B. van Ommen

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

De leergang wordt georganiseerd in nauwe samenwerking met:

BSc-programma’s: ‘Political Science’, ‘International Relations and Organisations’. MSc-opleiding: Political Science, met specialisaties ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

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