Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. M. Danhof

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Binnen de Life in Custody Study wordt grootschalig onderzoek gedaan naar het leefklimaat in Nederlandse penitentiaire inrichtingen (PI’s).

Despite their ecological, cultural, and economic importance, lion (Panthera leo) populations in Kenya are declining rapidly due to retaliatory killings following livestock depredation, depletion of wild prey, habitat loss driven by human activities, climate change, and disease.

Hoogleraar Data Science Aske Plaat was op 11 oktober te zien in het tv-programma Nieuwsuur tijdens een item over de mogelijkheden en gevaren van kunstmatige intelligentie. Het item was naar aanleiding van een symposium van de KNAW over de doorbraak in het spelen van Go met behulp van kunstmatige intelligentie.…

Positieve verwachtingen kunnen het gevoel van jeuk beïnvloeden en placebo-effecten oproepen, terwijl negatieve verwachtingen nocebo-effecten bij jeuk kunnen veroorzaken. Er zijn aanwijzingen dat placebo-effecten ook kunnen optreden wanneer mensen weten dat zij een placebo innemen. Er is weinig bekend…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Curved single crystals provide variable, but well-defined surface structures.

Promotor: E.F. Smets, Co-promotor: J. Geml

Promotores: H. Schiessel, G.T. Barkema

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Promotor: Prof.dr. H.J.A. Rottgering

Metal production is not only energy-intensive and a major source of greenhouse gas (GHG) emissions, but is also associated with other impacts affecting human health and ecosystems.

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

In this course, you will learn about sustainability and staying with the environmental boundaries of our planet. You will gain an understanding of the effects of growing affluence and population growth, the key challenges we are facing, and ways to influence your direct environment.

Overzicht van de vacatures bij de afdeling Economie.

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Zelfdenkende computers: hoe slim zijn ze, en vormen ze een gevaar voor de samenleving? Drie experts gaven op 9 februari hun mening hierover in Trouw. Een van de experts is hoogleraar Data science Aske Plaat. ‘Ik heb nog nooit een intelligent systeem gezien dat iets tegen de wil van de mens deed.’

Prof. dr. Aske Plaat (1966) wordt per 1 januari 2016 de nieuwe wetenschappelijk directeur van LIACS, het Informatica Instituut van de Universiteit Leiden. Plaat werkt sinds 1 juli 2014 als hoogleraar Data Science bij LIACS.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Promotie