The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Plastics have become an integral part of modern society due to their versatility and durability.

Elk onderdeel van de kringloop op een melkveebedrijf heeft een specifieke bacterie- en schimmelsamenstelling. Dat ontdekten de Leidse postdoc onderzoeker Sofia Gomes en haar begeleiders Nadia Soudzilovskaia en Peter van Bodegom in samenwerking met het Louis Bolk instituut en Naturalis Biodiversity Centre.…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotor: Prof.dr. G.P. van Wezel

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Studievoorlichting

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Supervisor: P.J.J. Hooykaas

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Co-creatie en multidisciplinair leren over grenzen heen.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Het doorvoeren van allerlei veranderingen, introduceren van nieuwe structuren, verdergaande regels en administratieve systemen lijken soms af te leiden van het bestaansrecht of de publieke opgave van de organisatie. Bovendien komt er meer erkenning voor de behoefte van medewerkers in publieke organisaties…

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Lees hier over geneeskunde docenten die middels de column 'Daarom Docent' laten zien wie zij zijn en wat ze doen in relatie tot onderzoek en lesgeven.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Het LAK biedt een groot aantal danscursussen aan. Het gevarieerde aanbod is voor zowel beginnende dansers als voor gevorderde dansers. Kwaliteit staat voor ons voorop, daarom werken we met professionele en bevlogen docenten. Het LAK benadert dans als podiumkunst. Aan het eind van de cursusreeks de…