GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Dit project digitaliseert en verenigt de Van Manen Collectie, zodat de vorming ervan bestudeerd kan worden en inzicht ontstaat in drukcultuur, kennisverspreiding en religieuze praktijken in Centraal-Tibet.

Hoe ervaar jij een stiller geworden stad? Amsterdam is normaliter bomvol geluid. Door de corona crisis is dat veranderd. Weinig tot geen mensen op straat, winkels gesloten, veel minder verkeer, nauwelijks overkomende vliegtuigen. Het geluidslandschap van de stad is totaal veranderd. Soundtrackcity,…

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: T. Schmidt

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Ik wil iets met Azië. Bij Universiteit Leiden zijn er verschillende bachelor opleidingen die jij kan volgen. Bekijk jouw mogelijkheden.

De master Asian Studies van de Universiteit Leiden is een hoogwaardige opleiding bij één van de meest vooraanstaande centra voor Aziëstudies in Europa.

Azië en Europa hebben in toenemende mate met elkaar te maken. Om een duurzame samenwerking te bevorderen is het belangrijk elkaar op economisch, sociaal-cultureel, historisch, en juridisch gebied beter te begrijpen. Leidse wetenschappers leveren al decennia een belangrijke bijdrage aan de verwerving…

Wat kunnen de talen die vandaag gesproken worden op de Kleine Soenda-eilanden ons vertellen over de geschiedenis van de verschillende bevolkingsgroepen?

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Het ‘Leer te Durven!’ programma is een preventieve training voor kinderen met lichte angstklachten (Simon & Bögels, 2014). Het programma is speciaal ontwikkeld voor kinderen tussen de 8 en 12 jaar die zich angstig voelen of angstig gedragen, situaties vermijden, bang zijn om dingen fout te doen, schrikachtig…

Het doel van ons onderzoeksprogramma Klinische Psychologie is om de etiologie en het verloop van stemmings-, angst- en stress-gerelateerde aandoeningen zoals depressie en posttraumatische stressstoornis (PTSS) beter te begrijpen.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Religion, Philosophy, and the Pre-modern World

Hoe transformeren verzekeringsproducten intieme en persoonlijke relaties? Wat zijn de gevolgen van de classificaties die verzekeringsmaatschappijen gebruiken en hoe beïnvloeden deze solidariteit, moraliteit en ongelijkheid?

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Het Skandapurāṇa Project, dat een internationaal consortium van wetenschappers verenigt, bestaat uit een team van onderzoekers die werkzaam zijn op verschillende gebieden van de geesteswetenschappen. We creëren een kritische editie van een fundamenteel werk uit de purāṇische literatuur en traceren zo…

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.

Kunst en vrije tijd, Kunst en vrije tijd

Fundamental research in the ALgebra, Geometry And Number Theory

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.