Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

De faciltieit ontwikkelt en gebruikt, high-throughputmethoden toe voor genomisch onderzoek.

Hoe kun je virussen als medicijn laten werken? Hoe kunnen bacteriën schadelijke stoffen in het milieu afbreken? Hoe worden algen omgevormd tot producenten van biobrandstof? Dit zijn typische vragen die je bij de opleiding LST behandelt. Je combineert de vakgebieden wiskunde, scheikunde, natuurkunde…

Hoe kun je virussen als medicijn laten werken? Hoe kunnen bacteriën schadelijke stoffen in het milieu afbreken? Hoe worden algen omgevormd tot producenten van biobrandstof? Dit zijn typische vragen die je bij de opleiding LST behandelt. Je combineert de vakgebieden wiskunde, scheikunde, natuurkunde…

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Technologies that help to enhance our educational environments can be found everywhere.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

Onderzoek uitgevoerd door eLaw, centrum voor recht en digitale technologie Universiteit Leiden in opdracht van Tracks Inspector Den Haag.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotie

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Details kunnen zien van een zieke of gezonde cel, dat is mogelijk met de supermicroscoop van het consortium Cyttron. Niet alleen de microscoop is vernieuwend in zijn soort: ook de vorm waarop de partijen samenwerken past in de huidige tijd. “Toegang tot elkaars techniek, daar draait het om in ons samenwerkingsverband”,…

Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.

Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.

Promotor: Prof.dr. T. Schmidt

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Prof.dr. G.P. van Wezel

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

February 10th-12th & 16th-19th, Opening Thursday February 9th, 17:00.

Promotor: Prof.dr. J. Kuiper

De opleiding Life Science and Technology (LST) stond 9 september 2014 met een feestelijk gebakje stil bij haar 15 jarig bestaan. Het gaat bijzonder goed met de opleiding. Er zijn veel eerstejaars studenten en LST masterstudenten vinden of vóór hun diploma-uitreiking of er vlak na een goede baan.

Hoe gebruiken studenten mobiele technologie voor hun zelfsturende taalleren? Welke factoren beïnvloeden hun zelfgestuurd leren met mobiele technologie?

De integratie van technologie in scholen wordt gezien als cruciaal voor het bereiken van digitale gelijkheid in het onderwijs, evenals voor schoolverbetering, en de kwaliteit van onderwijs en leren. We zien echter nog steeds onvoldoende of ineffectief gebruik van technologie in lesgeven en leren.

Op 20 maart 2019 verdedigde Tim Dekkers zijn proefschrift 'Mobility, Control and Technology in Border Areas: Discretion and Decision-making in the Information Age'. Het promotieonderzoek is begeleid door promotoren prof. dr. J.P. van der Leun en prof. dr. M.A.H. van der Woude.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

In opdracht van Tracks Inspector, een bedrijf dat innovatieve software ontwikkelt, doet eLaw onderzoek naar cyber agent technology voor inlichtingen- en veiligheidsdiensten.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotor: Prof.dr. R.M.H. Merks

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.