Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotor: Prof.dr. M. Ubbink

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotor: Roeland M.H. Merks

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Opdrachten maken, werkgroepen voorbereiden, deadlines halen en de eerste tentamens al in zicht! Met de Get Started-campagne van de Universitaire Bibliotheken Leiden helpen we nieuwe studenten hun weg te vinden in de bibliotheek. De hulp van docenten kunnen wij daarbij goed gebruiken.

Op 14 december 2016 verzorgde Steven L. Schwarcz, Stanley A. Star Professor of Law & Business aan Duke University School of Law de dertiende Hazelhoff Guest Lecture. Voorafgaand aan deze lezing organiseerde het Hazelhoff Centre for Financial Law een rondetafelgesprek met Professor Schwarcz en personen…

This thesis covers various applications of topology in condensed matter physics and quantum information.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

On dinsdag 26 september heeft Jessica Hill haar proefschrift ‘On the road to adulthood. Delinquency and desistance in Dutch emerging adults’ verdedigd. Promotor is Professor Arjan Blokland.