This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

“De kredietcrisis ligt achter ons, op naar economische groei!” De krantenkoppen geven ons weer hoop. Maar is sprake van een structureel herstel of wordt dit herstel gebouwd op een fragiel fundament?

Promotor: Prof.dr. G.J. Kroes

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Curved single crystals provide variable, but well-defined surface structures.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Wim Voermans, hoogleraar Staats- en Bestuursrecht, is als lid van een delegatie van de Universiteit Leiden, van 14 tot en met 18 maart afgereisd naar São Paolo, Brasilia en Rio de Janeiro om de banden met Brazilië te versterken. Tijdens het bezoek zijn afspraken gemaakt over verdere wetenschappelijke…

De Faculteit Rechtsgeleerdheid

Op 14 november 2019 verdedigde Luis Fiallos Pazmino zijn proefschrift 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. E.C.P.D.C. De Brabandere.

Is de kwaliteit van het huidige toezicht en handhaving door de overheid dusdanig dat hiermee de bedrijven die met grote hoeveelheden gevaarlijke stoffen werken tot naleving van de wet- en regelgeving worden gebracht?

In de specialisatie Cybersecurity Governance, onderdeel van MSc Crisis and Security Management, maak je kennis met de breedte, diepte en complexiteit van cybersecurity-uitdagingen. Deze track biedt je geavanceerde kennis over de governance- en regelgevingsstrategieën die beschikbaar zijn om deze uitdagingen…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Op 20 juni verdedigde Anne Hendrikx het proefschrift 'Methoden van contractsuitleg: een model voor de uitleg van een overeenkomst'. Het promotieonderzoek is begeleid door Henk Snijders.

Promotores: H.W. Lenstra, A. Lucchini

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Op donderdag 16 november 2017 heeft Lalin Kovudhikulrungsri haar proefschrift ‘The Right to Travel by Air of Persons with Disabilities’ verdedigd. Haar promotoren zijn Prof.dr. P.M.J. Mendes De Leon en Prof.mr.dr. A.C. Hendriks.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

In de zaak Ferreira da Silva e Brito e.a./Estado portugues heeft het Hof van Justitie in het kader van overgang van onderneming expliciet de luchtvaartsector als kapitaalintensieve sector aangewezen. Hoe verhoudt het arrest zich tot het oordeel van het Gerechtshof Amsterdam over de overgang van de passagedivisie…

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

Promotor: Prof.dr. C.W.J. Beenakker

In dit artikel onderzoeken Bart Schuurman & Sarah Louise Carthy de verschillen tussen geradicaliseerde individuen en de algemene bevolking.

Voormalige cliënten en projecten

Op 16 december 2016 vond aan de Universiteit Twente de jaarlijkse staatsrechtconferentie plaats, met dit jaar als thema constitutionele mogelijkheden en beperkingen voor experimenteel handelen en experimentele wetgeving.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Joery Matthys, universitair docent aan het Institute of Security and Global Affairs, bracht begin deze maand een ex ante evaluatie van het Contraterrorismebeleid uit.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Eenvoudig belasting heffen - tussen droom en daad