Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: Prof.dr. M. Danhof

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: S.M. Verduyn Lunel

Promotor: Prof.dr. A.W. van der Vaart

Promotor: K.J. Batenburg

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

Recentelijk is een Special Issue van de European Journal of Criminology verschenen, die is samengesteld door Marieke Liem, Universitair Docent Criminologie bij het Instituut voor Strafrecht & Criminologie, en William Pridemore.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Promotor: Prof.dr. C.W.J. Beenakker

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Dit gedeelte bevat een overzicht van onze alumni, het loopbaanperspectief naast het doctoraat en "Alumni in beeld", waar we enkele voorbeelden geven van de carrières van sommige van onze alumni na hun promotie.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

In de tweede helft van de negentiende eeuw groeide Amsterdam uit tot hoofdstad van Nederland. Maar zagen de negentiende-eeuwse Amsterdammers zichzelf ook als Nederlanders? Dit boek laat zien hoe dienstmeisjes en schoenmakers, winkeliers en schooljongens hun Nederlanderschap in het dagelijkse Amsterdamse…