Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: R. Gill, Co-promotor: P. Massart

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

Promotor: G.R. de Snoo

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: Prof.dr. A.W. van der Vaart

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Does roadside management in the mid-west USA increase invertebrate diversity similar to practices in Europe?

Stellar feedback is a crucial ingredient in the evolution of galaxies.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

A new publication on changes in the relationship between news and their public in Chile

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Promotor: J. Kuiper

Promotor: M.K. Richardson, Co-Promotor: F. Witte

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. J. Kuiper

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

In this thesis we study bistable reaction-diffusion equations on lattice domains.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.