In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

Het LIACS organiseert verschillende lezingenseries, zoals het LCN2 Seminars en de SAILS Lunch Time-seminars.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

Promotor: Prof. dr. A.G.G.M. Tielens

Een diepgaande geschiedenis en technische beschrijving van grote taalmodellen – en wat hun alomtegenwoordigheid, disruptieve kracht en creativiteit betekenen vanuit een breder sociaal-politiek perspectief.

Promotor: S.J. Edixhoven, L.D.J. Taelman

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotor: Prof.dr. M.K. Richardson

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

This thesis introduces the concept of

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Promotores: H. Schiessel, G.T. Barkema

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Elke dag nemen we vele beslissingen; van wat we eten tot hoe we de wereld om ons heen interpreteren. Over het algemeen gingen onderzoekers ervan uit dat een belangrijk onderdeel van ons besluitvormingsproces, namelijk het beslissingscriterium, stabiel blijft. Er zijn echter steeds meer aanwijzingen…

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

Elektrische signalen bewegen als een golf door onze zenuwbanen. De wiskundige modellen voor deze bewegingen konden nog niet alle biologische eigenschappen van de zenuwbanen goed beschrijven. Promovendus Willem Schouten-Straatman bracht hier verandering in door de bestaande modellen te verbeteren. 'Ik…

De huidige sociale normen zijn niet duurzaam, wat gedragsverandering een cruciale factor maakt in het aanpakken van de klimaatcrisis. Daarnaast kunnen sociale normen snel veranderen na een kantelpunt. Deze kantelpunten worden alleen vaak pas herkend door terug te kijken. Om verandering te stimuleren…

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.