The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Het Dual PhD Centre bestaat om een bijzondere groep promovendi aan de Universiteit Leiden extra ondersteuning te bieden: de duale promovendi.

Voordrachten in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus (aug. 2017 – dec. 2023).

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Sinds september 2010 werken Geerten Waling en Anne Heyer in het NWO project ‘The Promise of Organization’.

Niet alleen de ‘klik’ van een geneesmiddel met het doelmolecuul in het lichaam bepaalt de werking ervan, maar ook de tijd die het geneesmiddel op het molecuul doorbrengt. Leidse onderzoekers gaan met 15 miljoen euro een Europees consortium leiden om vanuit dit nieuwe concept betere medicijnen te mak…

Het JPAO is per 1 mei 2023 verder gegaan onder de naam Leiden Law Academy: de nieuwe naam voor de afdeling die het juridisch postacademisch onderwijs (Juridisch PAO) van onze faculteit organiseert en faciliteert. Hierbinnen is een nieuw eventbureau opgezet dat de congressen en events van de faculteit…

Ineens waren ze er, de Russische soldaten aan de grens met Oekraïne. Sindsdien domineren berichten over spanningen tussen Rusland enerzijds en de Verenigde Staten en Europa anderzijds het nieuws. Wat is er aan de hand? Een gesprek met Ruslandkenner André Gerrits.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

A new publication on changes in the relationship between news and their public in Chile

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. W.T.F. den Hollander

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis applies data mining in commercial settings in the telecommunications industry.

Promotor: C.J. ten Cate

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: J. Zaanen

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: A. Kros

Promotor: Prof.dr. T.H.W. Bäck

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Sommige bacteriën blijken net als wij eiwitten te hebben die het DNA in hun cellen organiseren. Die doen dat alleen net even anders. Dat blijkt uit nieuw onderzoek van bio-chemici van het Leiden Institute of Chemistry en het Max Planck Institute for Biology. De ontdekking helpt ons beter begrijpen hoe…

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. M. Ubbink