IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Promotor: S.J. Edixhoven

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

De Universiteit Leiden heeft in 2021 verder gewerkt aan het verkleinen van haar CO2-voetafdruk door zuiniger om te gaan met grondstoffen en het energieverbruik structureel te verminderen. Dat is te lezen in het Duurzaamheidsverslag 2021.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Een taks op de CO2-uitstoot van producten die de EU binnenkomen, biedt ongeziene mogelijkheden in de strijd tegen klimaatopwarming. Dat blijkt uit onderzoek waar de Leidse milieuwetenschapper Hauke Ward aan meewerkte. ‘Een nieuwe wereld gaat open’, zegt Ward. ‘Maar het succes staat of valt met hoe we…

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This dissertation presents new cryptographic protocols, which can be divided into two families.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

In dit artikel onderzoeken Thijs van Dooremalen en Philip Smith hoe het publieke discours over hittegolven is verschoven in Britse kranten.

Lezing

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

De CO2-voetafdruk van de universiteit is opnieuw kleiner geworden. Dat blijkt uit het Duurzaamheidsverslag 2022. Ook is verder gewerkt aan het integreren van duurzaamheid in het Leidse onderwijs en onderzoek.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Promotor: J. Aarts

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Uit de Duurzaamheidsmonitor 2023 blijkt dat de Universiteit Leiden haar duurzaamheidsinspanningen krachtig voortzet.

Hoe zorg je ervoor dat burgers meer betrokken zijn bij energietransitieprojecten? Dat is de hoofvraag van het nieuwe transdisciplinaire onderzoeksproject EmPowerEd. De Universiteit Leiden doet, als consortiumpartner mee en richt zich op effectieve en inclusieve samenwerking tussen burgers, gemeenten…

The global agri-food system plays a critical role in food security and environmental issues.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng