The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Promotor: M. Ubbink, Co-promotor: G. Siegal

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

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This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Het doel van de onderzoekers aan het LUCL is om bij te dragen aan een alomvattend en deskundig perspectief op het menselijk verleden.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…

Promotor: J. Schaye

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: Prof.dr. P.C. van Welzen

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Check hieronder de aanmelddeadlines voor de opleiding Molecular Science and Technology.

Promotie

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: H.J.M. de Groot

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Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

Stellar feedback is a crucial ingredient in the evolution of galaxies.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.