Oogst na oogst binnenhalen van rijstveld, zonder nieuwe rijstplanten te zetten? Door een ontdekking komt dit scenario misschien wel dichterbij. Leidse wetenschappers hebben een gen ontdekt waarmee ze eenjarige planten na het bloeien opnieuw laten groeien, in plaats van dat de planten sterven. Publicatie…

Leidse biologen hebben aangetoond dat een gen dat aanwezig is in planten, dieren en gisten wel degelijk een belangrijke rol speelt in planten, al werd daar jaren anders over gedacht. Zonder het gen blijkt de ontwikkeling van vaatweefsel in planten niet goed op gang te komen. Publicatie in Nature Plants…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Zonder een gewas opnieuw te zaaien toch nakomelingen produceren, die zelfs groter kunnen zijn dan de ouderplant. Volgens Leidse onderzoekers is dat mogelijk door het overstimuleren van één gen. Daarmee verjongt een cel en gaat deze terug naar de embryonale fase.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: Prof.dr. J.P. Abrahams

Cardiovascular diseases are still a major concern for the global health.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

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Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…

Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Promotor: W. Jiskoot, Co-promotor: A. Hawe

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Prof. Judith Bovée kreeg zaterdag een prijs uitgereikt op Zeldzame Ziektendag. De prijs is een blijk van waardering vanuit de gezamenlijke patiëntenverenigingen voor haar wetenschappelijk en diagnostisch werk op het gebied van zeldzame bottumoren.