To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Individuele moleculen zijn extreem moeilijk te zien via hun zwakke fluorescentie. Piepkleine gouden nanostaafjes fungeren als nieuwe antennes om hun signaal 500 maal te versterken. Publicatie op 24 februari in Angewandte Chemie.

Pas als we stap voor stap een plant of dier kunnen ‘bouwen’, begrijpen we hoe het organisme werkt. Zo kunnen we volgen en invoelen hoe eiwitten en DNA zich organiseren tot cellen en hoe cellen zich logischerwijs wel moeten organiseren tot weefsels, organen en hele dieren. Pas dan begrijpen we echt hoe…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Professor Hermen Overkleeft ontvangt de prestigieuze Roy L. Whistler International Award 2024 van de International Carbohydrate Orgasation. De prijs is een erkenning voor Overkleefts bijdrage aan de koolhydraat- en biochemie.

Prof. Jan Pieter Abrahams heeft een Technology Area (TA)-premie van 750.000 euro ontvangen. Twee derde van dit bedrag wordt door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Chemische Wetenschappen gefinancierd en een derde door het bedrijfsleven.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Promotor: M.A.G.J. Orrit

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Volgens het standaardrecept voor een quantumcomputer met Majorana’s als bouwstenen moet je ze omzetten in qubits. Maar een veelbelovende toepassing van quantum computing—quantumchemie—vereist dat deze qubits opnieuw transformeren, in zogenoemde fermionen. Natuurkundigen uit Leiden en Delft stellen voor…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: H.V.J. Linnartz

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Moleculen zijn de bouwstenen van het leven. Ze ontstaan door chemische reacties die plaatsvinden als atomen met elkaar botsen. In het ijle heelal zijn deze botsingen zeldzaam en de omstandigheden extreem. Toch zijn ook hier complexe moleculen te vinden en gebeuren er dus chemische reacties. Hoogleraar…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

Promotie

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Benieuwd naar de afgelopen lezingen? In het archief bewaren wij de presentaties en eventuele verslagen van onze lezingen.

De Leidse chemicus Sascha Hoogendoorn ontwikkelde synthetische moleculen die selectief worden opgenomen door bepaalde celtypes. Een belangrijke stap in de ontwikkeling van medicijnen met minimale bijwerkingen. Promotie 23 januari.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

In the first part of this thesis we study the geometry of folding patterns.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. M. Ubbink

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotie

Dit jaar start de Leidse microbioloog Arthur Ram met onderzoek om op grote schaal nuttige enzymen te produceren. Ram ontvangt een NWO-beurs voor het project dat toepassingen heeft in de industriële biotechnologie en voedingsindustrie.