The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Er zijn voor jou, als kandidaat van de selectie, twee routes die je kunt bewandelen. Afhankelijk van de route (A of B) wordt naar een aantal criteria gekeken. Voor route A kandidaten tellen de 5vwo-overgangscijfers mee; voor kandidaten uit route B niet. Welke route je moet volgen en of je een toelatingsverzoek…

Er zijn voor jou, als kandidaat van de selectie, twee routes die je kunt bewandelen. Afhankelijk van de route (A of B) wordt naar een aantal criteria gekeken. Voor route A kandidaten tellen de 5vwo-overgangscijfers mee; voor kandidaten uit route B niet. Welke route je moet volgen en of je een toelatingsverzoek…

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Studievoorlichting

Studievoorlichting

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotor: Prof.dr. J.N. Kok

De Leiden Slavery Studies Association (LSSA) is toegewijd aan het bevorderen van een beter begrip van slavernij en post-slavernij in elke periode en elk geografisch gebied.

Deze minor biedt een overzicht van het vakgebied Psychologie.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Hoe dachten de anglosaksen over de ervaring van het ouder worden? Was het echt een gouden tijd voor de ouderen zoals werd gesuggereerd?

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Bij Studeren à la carte of toehoorderschap is er sprake van aanschuifonderwijs: u schuift aan bij een reguliere collegereeks, zonder dat u tentamen aflegt. Na afloop ontvangt u een certificaat van deelname. Hierop staan geen studieresultaten (er is immers geen tentamen afgelegd).

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: J. A. Bouwstra

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Promotor: Prof.dr. J.W.M. Frenken

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

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Op deze pagina vind je alle informatie over de Bachelor Security Studies die je als aankomend student nodig hebt.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Promotor: Prof.dr. H.V.J. Linnartz

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.