2,153 zoekresultaten voor “state cell biology” in de Publieke website
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Orchid mycorrhizal interactions: evolutionary trajectories and ecological variations
The mycorrhizal symbiosis is among the most widespread species interactions on Earth. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Luc Verhey wordt lid van de Raad van State
Luc Verheij hoogleraar Staats en bestuursrecht (Kircheiner-leerstoel) in Leiden wordt lid van de Raad van State. Sinds 2011 is Verheij al staatsraad in de Afdeling advisering. Deze rol blijft hij vervullen en wordt daarnaast ook lid van deze Raad.
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Profiling and Immunotherapy in the Real-Life Clinical Setting in Non-Small Cell Lung Cancer
Promotie
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Characterization of age-associated immunity in atherosclerosis
Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…
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Mast cells in advanced atherosclerosis: from human plaque stability to new therapeutic targets
In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.
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Foreign intelligence in the digital age. Navigating a state of 'unpeace'.
Het The Hague Program for Cyber Norms, een onderzoeksprogramma van het Institute of Security and Global Affairs, heeft zijn eerste beleidsnota gepubliceerd. Hierin onderzoeken Dennis Broeders, Sergei Boeke en Ilina Georgieva de rol van inlichtingendiensten in cyberspace en de (on)mogelijkheden van adequate…
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(Non)recognition of legal identity in aspirant states: evidence from Abkhazia, South Ossetia and Transnistria
Ramesh Ganohariti onderzoekt de juridische identiteit in drie post-Sovjet aspirant-lidstaten en schetst in dit artikel vier veelvoorkomende scenario's.
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Rebel Legal Order, Governance and Legitimacy: Examining the Islamic State and the Taliban Insurgency
Dit artikel onderzoekt hoe ISIS en de Taliban steun hebben gekregen door hun parallelle rechtssystemen.
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Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace
Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.
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Into the ether or the state? Legibility theory and the cryptocurrency markets
In dit artikel presenteren Kellerman en Seddon een nieuw conceptueel kader waarin het concept van marktleesbaarheid centraal staat.
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Borders in Dispute: The Construction of State and Nation in International Diplomacy
How are borders drawn? More specifically, how do diplomatic actors manage the implications of changes in state sovereignty for international borders?
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informality of the international cybersecurity regime: Geopolitics, non-state actors and diplomacy
De auteurs analyseren twee belangrijke factoren die informaliteit verdiepen, namelijk multipolaire geopolitiek en de opkomst van niet-statelijke actoren.
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Small-State Influence in EU Security Governance: Unveiling Latvian Lobbying Against Disinformation
In dit artikel onderzoekt Sophie Vériter hoe een kleine staat het veiligheidsbestuur van de EU beïnvloedt.
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Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences
Op 28 februari 2019 verdedigde Kabir Duggal zijn proefschrift 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. Het promotieonderzoek is begeleid door promotor prof. dr. E. De Brabandere.
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Unpacking the effects of burdensome state actions on citizens' policy perceptions
In dit artikel onderzochten Martin Sievert en Jonas Bruder of en hoe administratieve lasten van invloed zijn op de perceptie van burgers van het welzijnsbeleid en hun houding tegenover uitkeringsgerechtigden.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Spatio-temporal aspects of antigen cross-presentation in dendritic cells: with click-to-release chemistry
The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.
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CD8+ T-cells in atherosclerosis, recognizing their contribution
Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Remko Offringa benoemd tot Opleidingsdirecteur masteropleiding Biology
Dr. Remko Offringa is met ingang van 1 september 2016 benoemd tot Opleidsingsdirecteur van de masteropleiding Biology. Hij volgt daarmee Johan Memelink op.
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Nieuw handboek “EU State Aids”
Het doet het Europa Instituut genoegen aan te kondigen dat deze week de 5e druk is verschenen van het handboek “EU State Aids” (31 hoofdstukken, 1500 pagina’s).
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Luuk ReinaldaWiskunde en Natuurwetenschappen
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
- Onderzoeksfaciliteiten
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Hearing what singing fish tell us about healthy oceans
Ontwikkelingen om de mariene biodiversiteit met hoge resolutie te meten, door ernaar te luisteren.
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Metabolomics study of blood vessels-on-chip model
Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Scattering and absorption in 2D optics
Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.
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‘Raad van State is het geweten van de overheid’
Al zijn de adviezen van de Raad van State niet bindend, ze zijn zeker gezaghebbend. Dat zei Piet Hein Donner of 4 februari tijdens een drukbezochte lezing aan de Rechtenfaculteit.
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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Dubbel succes bij de EMBL Chemical Biology Conference
Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Infographic eindrapport State of the Art Crisisbeheersing 2
State of the Art Crisisbeheersing 2
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Kevin GroenWiskunde en Natuurwetenschappen
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Protection of Environmental Refugees. A human rights-based, security and State responsibility approach
Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.
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inclusion of (post)colonial migrants in Dutch, French, and British welfare states, 1945-1970
Hoe werden (post)koloniale migranten opgenomen in de naoorlogse verzorgingsstaten?
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Importance of Religion in Spinoza's Thought and Its Implications for State and Society
Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…