Wil je je graag aanmelden voor Geschiedenis van Nederland in de Wereld aan de Universiteit Leiden? Doorloop dan de onderstaande stappen. We zien je aanmelding graag tegemoet!

Wil jij starten met een master opleiding aan Universiteit Leiden? Doorloop deze 6 stappen voor een succesvolle aanmelding.

Wil je je graag aanmelden de avondtrack Bestuur en Advisering van de Master Management van de Publieke Sector aan de Universiteit Leiden in Den Haag? Doorloop dan de onderstaande stappen. We zien je aanmelding graag tegemoet!

Wil jij beginnen aan een masteropleiding aan de Universiteit Leiden? Doorloop dan ons overzichtelijke stappenplan en meld je aan voor jouw master.

Wil je je graag aanmelden voor Nederlandkunde aan de Universiteit Leiden? Doorloop dan de onderstaande stappen. We zien je aanmelding graag tegemoet!

Wil je je graag aanmelden voor Ondernemingsrecht aan de Universiteit Leiden? Doorloop dan de onderstaande stappen. We zien je aanmelding graag tegemoet!

Wil je je graag aanmelden voor Staats- en bestuursrecht aan de Universiteit Leiden? Doorloop dan de onderstaande stappen. We zien je aanmelding graag tegemoet!

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: Prof.dr. M. Ubbink

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Nieuw onderzoek van de National University of Singapore en Leiden laat zien dat chimpansees en bonobo’s net zoveel contrast in hun ogen hebben als mensen, waardoor ze gemakkelijk de richting van iemands blik kunnen volgen.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Supervisor: P.J.J. Hooykaas