Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Promotie

Onderzoekers hebben een materiaal ontwikkeld dat ingaat tegen een van de basisprincipes van de natuurkunde. Reguliere materialen die ingedrukt worden, verspreiden de druk gelijkmatig, ongeacht waar die vandaan komt. Het nieuwe materiaal breekt met deze wetmatigheid en dat kan interessant zijn voor toepassingen…

Promotor: Prof.dr. M. Ubbink

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Every day, the intestines face an enormous challenge. They must absorb nutrients, medicines, and other substances we consume, while keeping harmful compounds out.

Transition graphs capture the memory and sequential response of multistable media, by specifying their evolution under external driving.

Antibiotic resistance is a growing global health threat, while the development of new antibiotics has slowed.

Bevorderen van studentenwelzijn en ontwikkeling van soft skills.

In dit project wordt onderzocht op welke aspecten van sociale-mediacontent adolescenten hun aandacht richten en hoe dit samenhangt met hun oordeel over de geloofwaardigheid van die content. Het doel is om systematisch inzicht krijgen in hun vatbaarheid voor desinformatie en om effectieve onderwijsprogramma’s…

Ga jij aan de Universiteit Leiden studeren in Den Haag? Doe dan mee aan de introductieweek de HOP en raak alvast wegwijs in de stad én het studentenleven.

Begin jij aan een master aan de Universiteit Leiden in Den Haag? Kom naar The HOP, de introductieweek voor alle nieuwe Haagse studenten.

Met de komst van socialemediakanalen als Twitter, Facebook en Instagram is het makkelijker dan ooit om informatie met elkaar te delen. Ook desinformatie. Tijdens zijn promotie ontwikkelde informaticus Xueqin Chen een nieuwe manier om nepnieuws te herkennen en te voorspellen hoe berichten zich binnen…

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Neurolaw is een relatief jonge discipline, waarin de impact van de neurowetenschappen op het recht, de juridische praktijk en de criminologie wordt onderzocht. De actuele ontwikkelingen binnen de neurowetenschappen (neurobiologie, -psychologie en -psychiatrie) hebben de betekenis van onderzoek op dit…

Den Haag kan jou op het gebied van sport en cultuur veel bieden. Naast je studie is er genoeg te doen in de studentenstad.

Op 23 januari is Kees Goudswaard met emiraat gegaan. Voor deze gelegenheid hebben zijn collega's een liber amicorum samengesteld.

Promotie

Stijve materialen breken gemakkelijker dan flexibele. Deze simpele constatering leidt tot een manier om de breedte van een barst te voorspellen en beheersen. Theoretisch begrip van hoe materialen breken is handig in bijvoorbeeld de productie van auto’s en beeldschermen. Publicatie in PNAS.