The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Deze tweejarige masteropleiding wordt aangeboden door het Leiden Institute of Chemistry en heeft een focus op technologische en fundamentele kennis en expertise. Tijdens de opleiding doe je onderzoek naar de processen van de levende cel met fundamenteel wetenschappelijke én toegepaste technologie. Je…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. H.S. Overkleeft

How can we bridge the gap between experts and the general public?

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

De overheid heeft baat bij de wetenschappelijke blik van promovendi, omdat de vraag naar ‘evidence based’ beleid groeit. Professor Sandra Groeneveld, verbonden aan het instituut Bestuurskunde, en haar promovendus Saniye Çelik, ambtenaar bij de Rijksoverheid, zijn hierover aan het woord in het magazine…

Soms is een idee op het eerste gezicht zo logisch, dat je je achteraf afvraagt waarom niemand er eerder op is gekomen. Twee onderzoekers van het LACDR hebben samen een volledig synthetisch alternatief voor antistoffen ontwikkeld. Een alternatief dat dezelfde grootte, vorm en werking heeft, maar goedkoper,…

Een nieuwe klasse polymeren is voor het eerst bij patiënten toegepast. Het gaat om de eerste nieuwe hulpstof in decennia die medicijnen beter oplosbaar maakt. Scheikundige Matthias Barz introduceerde de stof in 2014, die een uniek alternatief op de huidige opties biedt.

Onderzoekers vanuit verschillende vakgebieden werken samen om oplossingen te bedenken voor maatschappelijke problemen.

De overheid kan haar diversiteit beter benutten, zegt Saniye Çelik. Door mensen met verschillende achtergronden aan te nemen, kan de overheid makkelijker vraagstukken met burgers aanpakken. Werknemers voelen zich daardoor ook meer verbonden met de organisatie. Promotie 10 november.

Er heerst een onveilige werksfeer bij het politiekorps van Rotterdam centrum, Saniye Çelik vertelt over dit nieuws bij NPO Radio 1.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Dissociative chemisorption is an important reaction step in many catalytic reactions.

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Voor de omzetting van zonlicht naar brandstof

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

This thesis covers various applications of topology in condensed matter physics and quantum information.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. J.P. Abrahams