The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Kiemproject: Hoe kunnen metaforen bijdragen aan betere maatschappelijke betrokkenheid bij quantumwetenschap en -technologie, en welke factoren beïnvloeden de acceptatie of weerstand tegen metaforen bij zowel experts als leken?

Het belangrijkste doel is het onderzoeken van de mogelijkheid om het lichaam te leren een soortgelijke fysiologische (autonome, neuro-endocriene of immuunsysteem) en fysieke (b.v. desensibilisatie van hardnekkige lichamelijke symptomen) reactie te laten vertonen op placebomedicatie als op actieve medicatie…

Op 9 november verdedigde Roosmarijn van Es het proefschrift 'De psyche in de rechtszaal: over pro Justitia-rapportages in rechterlijke beslissingen over bewijs en straf in Nederland'. Het promotieonderzoek is begeleid door Jan de Keijser, Maarten Kunst en Janne van Doorn.

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

Het Leidse onderzoeksproject naar het leefklimaat in alle penitentiaire inrichtingen in Nederland wordt verlengd tot 2024. Hierdoor krijgt het al lopende project belangrijke nieuwe impulsen en kunnen meer vraagstukken worden onderzocht. Het Life-in-Custody project (LIC-project) is een samenwerking tussen…

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. M. Danhof

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

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Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Bij de Onderzoeksgroep Geweld en Geweldpreventie (Violence and Violence Prevention) wordt onderzoek gedaan naar de complexiteit van hedendaags geweld, de uiteenlopende verschijningsvormen ervan en strategieën voor preventie.

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Promotores: Wim Jiskoot; Ferry Ossendorp

Cardiovascular syndromes are the major cause of death in Western societies.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotor: V. Vitelli, Co-promotor: J. Paulose

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…