If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Al het onderzoek van de Universiteit Leiden is georganiseerd in instituten. Om recht te doen aan de veelkleurigheid van het onderzoek (en dus ook aan het onderwijs) dat daar uit voortvloeit vindt u op deze pagina’s omschrijvingen van alle Leidse instituten.

Het onderzoek van de programmagroep Onderwijswetenschappen richt zich op ‘het lerende kind in het onderwijs’. De focus ligt op processen die plaatsvinden tijdens de ontwikkeling en het leren.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Bepaalde ontwikkelingsfases en specifieke problemen van kinderen, zoals somberheid en angsten, vragen om specifieke benaderingen, waar ouders steeds opnieuw vorm aan moeten geven. Hoe wordt onderzoek naar ouderschap en de invloed hiervan op het welzijn van kinderen vormgegeven, en wat valt hiervan te…

This thesis focuses on addressing four research problems in designing embedded streaming systems.

In this course, you will develop an understanding of evolutionary processes and their formative power. You will see how evolution has shaped biodiversity, and continuously influences our daily life.

Deze minor richt zich op de cognitieve processen die invloed hebben op de wisselwerking tussen brein en bewustzijn.

Het onderzoek van Anne Helder toont aan wat in het brein gebeurt als lezers een tekst lezen waarin iets staat dat niet klopt. Promotie 15 november.

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Het begrijpen van individuele verschillen in zelfregulatie bij jongens met ODD/CD op het niveau van het brein, cognitie en gedrag

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: A. Kros

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Planets are formed in disks of gas and dust around young stars.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: J.W.M. Frenken

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Consequences for sediment stability and seston trapping

The applications of studying the early development of insects range from agriculture to material science.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: Prof.dr. T. Schmidt

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: Prof.dr. R.M.H. Merks