Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: M. Ubbink, Co-promotor: G. Siegal

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Zelfredzaamheid en sociale bescherming over de levenscyclus

Exoplanets close in to their host star receive high levels of extreme ultraviolet (EUV) irradiation, capable of heating and ultimately driving the hydrodynamic escape of their atmospheres.

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

Met het nieuwe studiejaar is bij de Honours Academy ook een nieuwe assessor aangetreden: Maarten Kolpa. Wat doet een assessor eigenlijk? En wat kan hij voor studenten betekenen? Maarten vertelt erover in een interview. “Ik vind het belangrijk dat het studentenperspectief vooropstaat.”

Ze vond alle studies interessant, maar koos voor Sterrenkunde. En nu ontrafelt hoogleraar Mariska Kriek de onstaansgeschiedenis van sterrenstelsels met de James Webb telescoop. KIJK-redacteur Laurien Onderwater praat met haar over haar over haar carrièrepad.

Cryptanalist Marc Stevens van het Centrum Wiskunde & Informatica (CWI) in Amsterdam, bekend van zijn 'kraak' van de MD5 hash-functie voor https-beveiliging in 2008, heeft deze week het recente Flame-virus geanalyseerd. Hij ontdekte dat voor deze spy malware een compleet nieuwe, tot nu toe onbekende…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Na 25 jaar is het deze december eindelijk zo ver: de lancering van de lang verwachte James Webb ruimtetelescoop. Leidse astronomen kijken vol spanning mee: niet alleen waren zij betrokken bij de bouw van belangrijke instrumenten aan boord, de telescoop zal ook vele nieuwe geheimen van het heelal onthullen,…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In this thesis,

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

This thesis is about the study of hydrocarbons via infrared spectroscopy.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.