This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

In het hoger onderwijs zijn open leermaterialen beschikbaar die iedereen mag gebruiken, maar ze worden niet zo veel gebruikt.

Het onderzoek richt zich op de vraag hoe op gemeentelijk niveau wordt omgegaan met klachten over jeugdhulp in het vrijwillige kader en welke rol (gemeentelijke) Kinderombudsmannen hierin spelen, door middel van kwalitatief onderzoek.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotor: Prof.dr. M. Ubbink

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

De Universiteit Leiden en de gemeente Leiden willen een nieuw plan gaan maken om een alternatieve Humanities Campus in de binnenstad te realiseren. Daarmee komt er geen onteigeningsprocedure voor het woningbouwcomplex De Doelen ten behoeve van de bouw van de nieuwe Humanities Campus voor de Faculteit…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

De Universiteit Leiden kan binnen haar beschikbare eigen grond een alternatieve Humanities Campus bouwen op de huidige locatie in de stad. Dit is de conclusie van een haalbaarheidsstudie. Het college van burgemeester en wethouders van de gemeente Leiden schrijft dit in een brief aan de gemeenteraad.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Vanaf 15 augustus a.s. worden er sloopwerkzaamheden uitgevoerd in de omgeving van het LMUY gebouw. De werkzaamheden vinden plaats op maandag t/m vrijdag tussen 07:00 en 19:00u. De aannemer is geïnformeerd dat het veroorzaken van trillingen zo veel mogelijk voorkomen moet worden.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

In dit artikel onderzoeken de onderzoekers hoe solidariteit begrepen kan worden, rekening houdend met de diversiteit van verhalen, ruimtes, praktijken, lichamen en tijdsperiodes in een stad.

Op 14 december 2016 verzorgde Steven L. Schwarcz, Stanley A. Star Professor of Law & Business aan Duke University School of Law de dertiende Hazelhoff Guest Lecture. Voorafgaand aan deze lezing organiseerde het Hazelhoff Centre for Financial Law een rondetafelgesprek met Professor Schwarcz en personen…

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.