Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: K.H. Kuijken

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Congres/symposium

Promotie

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Promotor: S.M. Verduyn Lunel

Veel van de grote uitdagingen van de 21ste eeuw (klimaatverandering, internationale migratie, financiële instabiliteit, sociaal-economische ongelijkheid) vinden hun oorsprong in de organisatie van de wereldeconomie. Elke oplossing voor de grote uitdagingen van de wereld vereist daarom krachtige beleidsinterventies…

De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

Julia Prümmer, Tommy van Steen en Bibi van den Berg evalueren de effectiviteit van cybersecuritytrainingen voor eindgebruikers.

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.

Wij zetten ons als faculteit in voor een rechtvaardige en veilige samenleving. Sinds 1575 hebben wij gebouwd aan onze wereldwijd erkende kennis en expertise.

Contactgegevens van het Europa Instituut

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

Het collegeaanbod op het gebied van de kunsten (voornamelijk beeldende kunst en muziek) en van cultuur in de breedste zin.

De leerstoel Democratische Vertegenwoordiging in het Koninkrijk richt zich op de politieke relaties tussen Europees Nederland en de zes Caribische eilanden in het Koninkrijk; de zogenaamde Koninkrijksrelaties. In het kader van de leerstoel doet Prof. dr. Wouter Veenendaal onderzoek naar de kwaliteit…

Prof. mr. Benjamin Marius Telders, hoogleraar volkenrecht, stierf op 6 april 1945 in Bergen-Belsen aan vlektyfus. Voor en tijdens de bezetting was hij een voorbeeld van burgermoed. Hij streed tegen willekeur en onrecht.

Het Instituut voor Regiostudies (LIAS) doet interdisciplinair onderzoek naar Azië en het Midden-Oosten, van de oudheid tot nu.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

Promotor: G.P. van Wezel

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Promotores: Wim Jiskoot; Ferry Ossendorp

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: Roeland M.H. Merks