Het Instituut Bestuurskunde van de Universiteit Leiden is gevestigd in het bestuurlijke hart van Nederland, in Den Haag. Vanuit deze centrale locatie verbindt het instituut wetenschappelijk onderzoek met de praktijk om actuele vraagstukken uit binnen- en buitenland aan te pakken.

In de afgelopen 30 jaar zijn er ruim 5000 planeten ontdekt buiten ons zonnestelsel. Een veelvoorkomende exoplaneet is de lavawereld, een hete superaarde met oceanen van vloeibaar lava. Mantas Zilinskas ontwikkelde modellen om mogelijke atmosferen daarvan te simuleren. Die simulaties bieden houvast voor…

Lees hier alles over de extra financiële middelen die de Rijksoverheid beschikbaar stelt vanuit het Nationaal Programma Onderwijs.

Studievoorlichting

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Fundamental research in the ALgebra, Geometry And Number Theory

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Promotor: Prof.dr. T.H.W. Bäck

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Promotor: Prof.dr. S.F. Portegies Zwart

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.