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1,485 zoekresultaten voor “mathematics biology” in de Publieke website

• The Monetary Valuation of Water-related Ecosystem Services Onderzoeksoutput

  While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

• Spatio-temporal aspects of antigen cross-presentation in dendritic cells: with click-to-release chemistry Onderzoeksoutput

  The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

• Advancing image-based localization of lipid-based nanomedicines for the exploration of targeted drug delivery Onderzoeksoutput

  Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

• Design and Synthesis of Click Lipids as Tools to Study Immune Cell Metabolism Onderzoeksoutput

  This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

• The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli Onderzoeksoutput

  Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

• Bioorthogonal chemistry to unveil antigen processing events Onderzoeksoutput

  The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

• Genetic diversity in the lion (Panthera leo (Linnaeus 1758)): unravelling the past and prospects for the future Onderzoeksoutput

  Promotor: Prof.dr. G.R. de Snoo

• Human-lion conflict around nairobi national park Onderzoeksoutput

  Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

• Coiled-coils on lipid membranes: a new perspective on membrane fusion Onderzoeksoutput

  Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

• Diversity in the globally intertwined giant barrel sponge species complex Onderzoeksoutput

  This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

• 
  Jos van den Broek Emeritus hoogleraar

  Faculteit Geneeskunde

• Aanmeldingsprocedure Leraar VHO in Natuurkunde (MSc)

• Aanmeldingsprocedure Leraar VHO in Griekse en Latijnse taal en cultuur (MA)

• Aanmeldingsprocedure Leraar VHO in Biologie (MSc)

• Aanmeldingsprocedure Leraar VHO in Nederlands (MA)

• Aanmeldingsprocedure Leraar VHO in Chinese taal en cultuur (MA)

• Aanmeldingsprocedure Leraar VHO in Bedrijfseconomie (MA)

• Aanmeldingsprocedure Leraar VHO in Frans (MA)

• Aanmeldingsprocedure Leraar VHO in Informatica (MSc)

• Aanmeldingsprocedure Leraar VHO in Maatschappijleer en maatschappijwetenschappen (MA)

• Aanmeldingsprocedure Leraar VHO in Godsdienst en levensbeschouwing (MA)

• Aanmeldingsprocedure Leraar VHO in Scheikunde (MSc)

• Aanmeldingsprocedure Leraar VHO in Duits (MA) (60EC)

• Aanmeldingsprocedure Leraar VHO in Algemene economie (MA)

• Aanmeldingsprocedure Leraar VHO in Wiskunde (MSc)

• Aanmeldingsprocedure Leraar VHO in Filosofie (MA)

• Aanmeldingsprocedure Leraar VHO in Geschiedenis en staatsinrichting (MA)

• Aanmeldingsprocedure Leraar VHO in Engels (MA)

• Plant Sciences Onderzoeksproject

  De missie van het Plant Sciences onderzoeksprogramma is om bij te dragen aan de duurzame productie van gewassen van hoge kwaliteit, bloemen en hoogwaardige producten met een biologische basis. Dit wordt gerealiseerd door het opdoen van fundamentele kennis over biologische processen omtrent de ontwikkeling…

• Design of branched swainsonines as selective Colgi alpha-mannosidase II inhibitors Onderzoeksoutput

  Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

• Elastin-like polypeptide micelles for vaccine delivery Onderzoeksoutput

• Design of selective inhibitors for human immunoproteasomes Onderzoeksoutput

  The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

• MAGL modulators: structure-guided optimisation and characterisation Onderzoeksoutput

  The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

• Animal Sciences Onderzoeksproject

  Wij voeren multidisciplinair onderzoek uit op het niveau van moleculen, cellen en organismen binnen de dierkunde. Ons doel is om fundamentele kennis te vergroten over gezondheid en ziekte.

• Biodiversity and Sustainability (MSc)

  In deze opleiding streef je naar het beantwoorden van biologische vraagstukken in relatie tot milieu, ecologie en andere maatschappelijk relevante onderwerpen.

• Microbial Biotechnology Onderzoeksproject

  In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

• Microbial Biotechnology Onderzoeksproject

  In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

• Molecular Genetics and Biotechnology (MSc)

  Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.

• Exploring the Versatility of Human β-Glucosidases and Related Glycosylated Metabolites with Novel Chemical Tools Onderzoeksoutput

  Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

• Inhibitors and probes targeting endo-glycosidases Onderzoeksoutput

  The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

• Design and synthesis of next generation carbohydrate-mimetic cyclitols: towards deactivators of inverting glycosidases and glycosyl transferases Onderzoeksoutput

  Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

• Savannah Landscapes for the future Onderzoeksoutput

  Celebrating 20 years of Environmental Research and Education in Northern Cameroon

• Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases Onderzoeksoutput

  This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

• 
  Emma Brakkee Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

• Pascal Professor 2015 Nieuws - 10 december 2014

  In 2015 the Pascalchair of the Faculty of Science, Universiteit Leiden and in particular of Leiden Institute of Advanced Computer Science, is held by Prof. Dr. Natasa Jonoska, University of South Florida, Tampa, USA.

• Delegatie van de Faculteit W&N bezoekt Indonesië Nieuws - 10 april 2015

  Een delegatie van de Faculteit Wiskunde en Natuurwetenschappen bezocht vier universiteiten en de hortus botanicus van Bogor, in Indonesië. Tijdens het bezoek werden concrete afspraken gemaakt met alle bezochte universiteiten over de uitwisseling van staf en studenten. Bovendien werd gesproken over samenwerking…

• Student projects Science Communication and Society

  To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

• Burger geeft graag inzicht in griepontwikkeling Nieuws - 2 februari 2016

  Mensen leveren graag een bijdrage van wetenschappelijke waarde door mee te doen aan De Grote Griepmeting, merkt Anne Land. Ze publiceert erover in Journal of Science Communication.

• Targeting of antigen-presenting cells with mannosylated conjugates Onderzoeksoutput

  This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

• Toxicity, bioaccumulation and trophic transfer of engineered nanoparticles in the aquatic environment Onderzoeksoutput

  The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…