In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

Promotores: R. Tijdeman, K.J. Batenburg

Promotor: H.W. Lenstra

Promotor: Peter Stevenhagen

Promotor: S.J. Edixhoven

Promotores: Bas Edixhoven, Jean-Benoit Bost, Co-promotor: Robin de Jong

Hoe kun je het getal pi benaderen met tandenstokers? Hoe rekenden de Babyloniërs? Zijn er wel normale getallen? Hoeveel is een triljoen eigenlijk? Hoe bereken je de ware liefde? Wat is het vermoeden van Kepler? En wat is binair rekenen eigenlijk?

Promotor: R. Tijdeman, Co-promotor: C. Kraaikamp

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Het Mathematisch Instituut is een van de acht instituten van de Faculteit der Wiskunde en Natuurwetenschappen. Het instituut opereert als een eenheid gedefinieerd door de activiteiten van de medewerkers.

Wiskundemeisje, wetenschapsjournalist en alumna Ionica Smeets zat gisteravond drie uur lang aan tafel bij Zomergasten-presentator Wilfried de Jong.

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Promotor: A.W. van der Vaart

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: J.H. Evertse

De 21e eeuw is getuige van een revolutie in ons begrip van rationale punten op oppervlakken en hoger-dimensionale variëteiten, en het is binnen dit vakgebied dat dit project zich bevindt.

n this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this.

Promotor: W.Th.F. den Hollander

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

This thesis consists of three chapters, the first two of which concern division points of elements of the multiplicative group of a number field.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp

Een uitgebreid overzicht van het onderzoek van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website

Een uitgebreid overzicht van software en data beschikbaar gesteld door de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website

Een uitgebreid overzicht van het onderwijs van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website

Over de hele wereld staan koraalriffen onder druk. Zarinah Waheed onderzocht de riffen in Maleisië en komt tot de conclusie dat de bescherming van koraalriffen beter kan. Promotie op 22 november.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: Prof.dr. G.R. de Snoo

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.