The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Een team van Leidse en Groningse studenten is door naar de Europese finale van de BISC-E competitie. In deze jaarlijkse wedstrijd moeten studenten een duurzame oplossing bedenken voor een groot maatschappelijk probleem. Het team bedacht SuckerSpheres: een natuurlijk alternatief voor de plastic microbeads…

Promotor: J. Schaye

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: Prof.dr. P.C. van Welzen

Tijdens de nieuwjaarsreceptie van de Faculteit der Wiskunde en Natuurwetenschappen op 6 januari 2015 is bekend gemaakt dat Annelien Zweemer, Leiden Academic Centre for Drug Research, is benoemd tot Ontdekker van het jaar 2014. Matteo Brogi, Leidse Sterrewacht, heeft het beste proefschrift van 2014 geschreven…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Check hieronder de aanmelddeadlines voor de opleiding Molecular Science and Technology.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: G.P. van Wezel

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: Roeland M.H. Merks

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Control of infectious diseases poses continuous challenges for human health.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotor: Prof.dr. B. van de Water

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Promotores: A.H. Meijer, H.P. Spaink

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: H.J.M. de Groot