State of the Art Crisisbeheersing 2

Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.

Hoe werden (post)koloniale migranten opgenomen in de naoorlogse verzorgingsstaten?

Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

De Raad van State heeft geschiedenis geschreven met zijn verrassende uitspraak vorige maand inzake de gaswinning in Groningen. Dat stelde de Groningse hoogleraar Herman Bröring dinsdag tijdens een gastcollege aan de Universiteit Leiden. De Raad van State vernietigde een besluit van minister Kamp. Een…

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

The applications of studying the early development of insects range from agriculture to material science.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Linde Desmaele onderzoekt de rol van Amerikaanse tactische kernwapens in Europa. Zij stelt dat deze wapens voornamelijk dienen als instrumenten voor bondgenootschapsbeheer.

Deze maand publiceerde Johan Christensen, assistent professor aan het Instituut Bestuurskunde, zijn nieuwe boek: 'The Power of Economists within the State. In het boek analyseert hij waarom bepaalde landen verschillend beleid ten opzichte van economische deregulatie hebben geïmplementeerd. Daartoe onderzoekt…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Hoe en in welke mate beïnvloedt AI de vertegenwoordiging van burgers in openbare dienstverlening en interacties tussen staat en burger?

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Op 3 oktober streed een team van het Instituut Biologie Leiden tegen andere universitaire biologenteams in de Biology Battle of the Universities. Het team behaalde de tweede plaats.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: Prof.dr. M. Ubbink

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

On 12 September 2019, Judge Chile Eboe-Osuji, President of the International Criminal Court (ICC), delivered a lecture on Customary International Criminal Law and Head of State Immunity to open the academic year for the Advanced LL.M. Programmes in Public International Law & International Dispute Settlement…

In het kader van de Honours Course ‘Crises in Biology’ die plaatsvond van 19 augustus t/m 2 september 2012 in Normandië, bezochten studenten vele geologische interessante locaties. Een van deze bijzondere plekken was de kust van Arromanches. Hier bemachtigden zij een enorm grote ammoniet die ze dinsdag…

De Raad van State heeft een programma van reflectie opgesteld, waarmee de hoogste bestuursrechter zijn aandeel in de kindertoeslagaffaire wil evalueren om lessen uit de affaire te kunnen trekken.

Promotores: H. Schiessel, G.T. Barkema