Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

De Universiteit Leiden staat midden in de maatschappij en wil bijdragen aan een duurzame samenleving. Verduurzaming van gebouwen levert een bijdrage aan Nederlandse en Europese milieunormen. De Universiteit Leiden houdt daar in al haar bouwprojecten rekening mee.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

De ‘Verdieping Bewaken en Beveiligen’ brengt verdieping aan op actuele gebeurtenissen en ontwikkelingen gerelateerd aan het stelsel Bewaken en Beveiligen.

Promotor: Prof.dr. M. Ubbink

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this work, we attempt to answer the question:

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

In this thesis, we present new laboratory data of interstellar dust analogues.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: W.T. de Groot

Artful Mathematics: The Heritage of M. C. Escher

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotores: J.N. Kok, H.J. Hoogeboom

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Promotor: T.H. Oosterkamp

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Including modelling as part of software development appears to have various benefits.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.

Promotor: Prof.dr.ir. E. Deprettere

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.