Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: F.J. van Lunteren, E. Jorin

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Promotor: M. Ubbink, Co-promotor: G. Siegal

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

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Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Op voordracht van prof.dr. Roderich Suessmuth van de Technische Universiteit van Berlijn ontving prof.dr. Herman Overkleeft de Friedrich Wilhelm Bessel Research Award. Van Overkleeft is in Leiden verbonden aan het Leiden Institute of Chemistry, LIC/Bio-organic Synthesis.

hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Overkleeft

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.