In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: E.F. Smets Co-promotor: J. Geml

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

The origin and evolution of galaxies are closely linked to many different physical phenomena.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

De motivatie van studenten van lerarenopleidingen voor het beroep van leraar is afhankelijk van diverse factoren. Lerarenopleidingen kunnen de betrokkenheid van hun studenten beïnvloeden.

Ontwikkeling van effectieve VR-training voor internationaal recht van gewapende conflicten (ILAC)

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Het doel van dit promotieonderzoek was te onderzoeken wat leraren zelf willen leren. De centrale onderzoeksvraag luidde: wat, hoe en waarom willen leraren leren? En hangt dit af van hun jaren leservaring en de school waarin ze werken?

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

Promotie

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Consequences for sediment stability and seston trapping

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

The overarching goal of this PhD thesis is to investigate the taxonomic and functional diversity of yeasts in the wheat phyllosphere and their interactions with the mycotoxigenic fungal pathogen Fusarium graminearum.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

The global agri-food system plays a critical role in food security and environmental issues.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Cynthia van Vonno, politicoloog aan de Universiteit Leiden, verklaart in haar proefschrift waarom individuele parlementariers meestemmen met hun fractie.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

Nieuw onderzoek van de National University of Singapore en Leiden laat zien dat chimpansees en bonobo’s net zoveel contrast in hun ogen hebben als mensen, waardoor ze gemakkelijk de richting van iemands blik kunnen volgen.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

In dit artikel onderzoeken de auteurs de mate van domesticatie van buitenlandse gebeurtenissen als onderzoeksonderwerp.

Als onderdeel van het Akkoord van Parijs kwamen landen over de hele wereld overeen om ontwikkelingslanden te steunen bij het investeren in klimaatmitigatie en -adaptatie via een Green Climate Fund. Ontwikkelde landen zijn er echter niet in geslaagd om de financieringsverplichtingen voor het Green Climate…

Promotor: M.A.G.J. Orrit

Promotie

Op 12 october promoveert Fatemeh Tabassi Mofrad. Het Leiden University Centre for Linguistics feliciteert Fatemeh!

Het is van cruciaal belang voor de demoratie dat jonge mensen de waarde leren van vrije, open discussie. Zelfs als het gaat om gevoelige onderwerpen als terrorisme. Dit betogen Thorbjørn Jagland (secretaris-generaal van de Raad van Europa), Sayeeda Warsi (lid van het Britse parlement) en Francesco Ragazzi…

Een onderzoek naar de ontwikkeling van prosociaal gedrag.