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De verhoogde activatie van het striatum, die adolescenten laten zien bij beloning, wordt meestal in verband gebracht met risicogedrag en negatieve gezondheidseffecten. In dit artikel in Nature Communications wordt een mogelijke positieve kant van die verhoogde activatie onderzocht. De activatiepiek…

In this dissertation several settings in the Online Learning framework are studied. The first chapter serves as an introduction to the relevant settings in Online Learning and in the subsequent chapters new results and insights are given for both full-information and bandit information settings.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?

In dit proefschrift staan de verschillende vormen centraal die de verwevenheid van onderzoek en onderwijs kan innemen binnen de universiteit, meer specifiek in de faculteit Geesteswetenschappen. Algemeen wordt erkend dat een sterke verwevenheid van onderzoek en onderwijs belangrijk is, maar het was…

In this article, Eamon Aloyo argues that university supervisors should not use student evaluations of teachers as a measure of teaching effectiveness.

Dit proefschrift richt zich op de opvattingen en percepties van Chinese en Nederlandse docenten over de rol van onderzoek in het hoger onderwijs.

In het proefschrift van Max Kusters (promovendus bij het ICLON) werd ‘teacher agency’ onderzocht: het vermogen van universitaire docenten om hun onderwijspraktijk en werkomstandigheden actief en doelgericht te beïnvloeden.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Promotor: Prof.dr. C.W.J. Beenakker

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: G.R. de Snoo

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De masterspecialisatie Philosophical Perspectives on Politics and the Economy van de Universiteit Leiden was voorheen bekend onder de naam Philosophy, Politics and Economics.

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: P.M. Brakefield

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Behalve de padden, gaan ook salamanders aan de wandel als het kwik enigszins stijgt. De salamanders leggen een afstand van tientallen tot honderden meters af naar het water waar ze zich voortplanten. Evolutionair bioloog Manon de Visser vertelt erover in Vroege Vogels, tijdens de uitzending van 9 fe…

Patrick Overeem universitair docent aan het Instituut Bestuurskunde is door het College van Bestuur van de Universiteit toegelaten tot de Leiden Teachers’ Academy.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid